{"id":52669,"date":"2018-07-03T11:11:16","date_gmt":"2018-07-03T11:11:16","guid":{"rendered":"https:\/\/www.humanitas.net\/?post_type=wiki&#038;p=52669"},"modified":"2018-07-03T11:11:36","modified_gmt":"2018-07-03T11:11:36","slug":"cefoxitina","status":"publish","type":"wiki","link":"https:\/\/www.humanitas.net\/ro\/wiki\/ingrediente-active\/cefoxitina\/","title":{"rendered":"Cefoxitina"},"content":{"rendered":"<p>Cefoxitina este un antibiotic care apar\u021bine categoriei cefamicinelor, molecule care sunt produse de bacteria Streptomyces lactamdurans \u0219i care intr\u0103 \u00een grupul de cefalosporine de a doua genera\u021bie. \u00cen general, cefoxitina \u0219i cea de-a doua genera\u021bie de cefalosporine sunt caracterizate prin faptul c\u0103 au un spectru larg de ac\u021biune care este eficace at\u00e2t pe bacterii Gram-pozitive, c\u00e2t \u0219i pe bacterii Gram-negative. De asemenea, au propriet\u0103\u021bi farmacocinetice.<\/p>\n<p>Din punct de vedere molecular, Cefoxitina ac\u021bioneaz\u0103 prin inhibarea sintezei peretelui bacterian. Ca \u0219i alte cefalosporine, acest antibiotic are capacitatea de a se lega de enzimele transpeptidazei care servesc la crearea leg\u0103turilor dintre lan\u021burile peptidoglican (polimerii esen\u021biali pentru formarea peretelui bacterian). La r\u00e2ndul s\u0103u, activitatea enzimelor transpeptidazice inhib\u0103 stabilitatea peretelui celular bacterian, duc\u00e2nd la moartea celulelor bacteriene \u00een cre\u0219tere.<\/p>\n<p>Spectrul de activitate al cefoxitinei este destul de similar cu cel al Cefamandolului. Este mai pu\u021bin eficace dec\u00e2t cefalosporinele de prima genera\u021bie \u0219i se sprijin\u0103 pe bacteriile gram pozitive; cu toate acestea, este foarte eficient \u00eempotriva bacteriilor anaerobe.<\/p>\n<h2>Ce este Cefoxitin?<\/h2>\n<p>Cefoxitin este utilizat pentru a trata infec\u021biile cu bacterii anaerobe sau infec\u021biile mixte aerobe-anaerobe. Este, de asemenea, utilizat pentru a trata infec\u021biile intra-abdominale (de exemplu, apendicita: inflama\u021bia anexei) \u0219i anumite infec\u021bii ale tractului genital feminin. Este cel mai eficient \u00eempotriva infec\u021biilor cauzate de bacteriile gram-negative care sunt rezistente la terapia cu antibiotice \u0219i cauza posibil\u0103 a bolilor mai severe.<\/p>\n<h2>Cum ar trebui s\u0103 fie luat Cefoxitin?<\/h2>\n<p>Cefoxitina se administreaz\u0103 parenteral sub form\u0103 de sare de sodiu (sub form\u0103 de pulbere \u0219i solu\u021bie de solvent care trebuie injectat\u0103 intramuscular sau intravenos).<\/p>\n<p>Efecte secundare asociate cu Cefoxitin<\/p>\n<p>Tratamentul de baz\u0103 cu Cefoxitin este \u00een general bine tolerat. Cele mai frecvente efecte secundare observate \u00een special la persoanele sensibile includ urm\u0103toarele:<\/p>\n<ul>\n<li>Tulbur\u0103ri gastro-intestinale: grea\u021b\u0103, v\u0103rs\u0103turi, diaree, dureri abdominale;<br \/>\n\u2022 Anomalii ale func\u021biei renale: leziuni glomerulare \u0219i tubulare, anomalii ale urinare, proteinurie;<br \/>\n\u2022Anomalii ale func\u021biei hepatice: cre\u0219terea valorilor transaminazelor; cre\u0219terea bilirubinei;<br \/>\n\u2022Anomalii hematologice: anemie hemolitic\u0103, leucopenie, neutropenie;<br \/>\n\u2022Simptome neurologice: letargie, spasme;<br \/>\n\u2022 Reac\u021bii alergice: m\u00e2nc\u0103rime, urticarie, angioedem, bronhospasm, hipotensiune arterial\u0103, reac\u021bii anafilactice.<\/li>\n<\/ul>\n<p>Contraindica\u021bii \u0219i avertismente asociate cu utilizarea Cefoxitinei<br \/>\nO aten\u021bie deosebit\u0103 trebuie acordat\u0103 administr\u0103rii acestui medicament la pacien\u021bii cu disfunc\u021bie renal\u0103 \u0219i hepatic\u0103. \u00cen orice caz, \u00een timpul administr\u0103rii acestui medicament, se recomand\u0103 monitorizarea func\u021biei renale \u0219i hepatice a pacientului. P\u00e2n\u0103 \u00een prezent, nu exist\u0103 date suficiente pentru a detecta posibila utilizare sigur\u0103 a acestui medicament \u00een timpul sarcinii \u0219i, prin urmare, nu este recomandat\u0103 femeilor \u00eens\u0103rcinate. \u00cen caz de urgen\u021b\u0103 sau de necesitate real\u0103, Cefoxitin poate fi administrat, totu\u0219i numai sub supraveghere medical\u0103 strict\u0103. Deoarece are tendin\u021ba de a se acumula \u00een laptele matern, trebuie s\u0103 decide\u021bi dac\u0103 dori\u021bi s\u0103 \u00eentrerupe\u021bi al\u0103ptarea sau s\u0103 \u00eentrerupe\u021bi tratamentul cu medicamentul, lu\u00e2nd \u00een considerare importan\u021ba medicamentului pentru s\u0103n\u0103tatea matern\u0103. Utilizarea Cefoxitinei trebuie \u00eentotdeauna s\u0103 fie precedat\u0103 odat\u0103 ce organismul este izolat \u0219i identificat. Acest lucru se face, \u00een general, prin detectarea sensibilit\u0103\u021bii \u0219i susceptibilit\u0103\u021bii microorganismelor la cefamicine.<\/p>\n","protected":false},"author":11,"featured_media":0,"template":"","wiki-categories":[1869],"wiki-types":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v19.7.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Cefoxitina - Humanitas.net<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.humanitas.net\/ro\/wiki\/ingrediente-active\/cefoxitina\/\" \/>\n<meta property=\"og:locale\" content=\"ro_RO\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Cefoxitina - Humanitas.net\" \/>\n<meta property=\"og:description\" content=\"Cefoxitina este un antibiotic care apar\u021bine categoriei cefamicinelor, molecule care sunt produse de bacteria Streptomyces lactamdurans \u0219i care intr\u0103 \u00een grupul de cefalosporine de a doua genera\u021bie. \u00cen general, cefoxitina \u0219i cea de-a doua genera\u021bie de cefalosporine sunt caracterizate prin faptul c\u0103 au un spectru larg de ac\u021biune care este eficace at\u00e2t pe bacterii Gram-pozitive, [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.humanitas.net\/ro\/wiki\/ingrediente-active\/cefoxitina\/\" \/>\n<meta property=\"og:site_name\" content=\"Humanitas.net\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/HumanitasInternational\/\" \/>\n<meta property=\"article:modified_time\" content=\"2018-07-03T11:11:36+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary\" \/>\n<meta name=\"twitter:site\" content=\"@humanitasmilano\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.humanitas.net\/ro\/wiki\/ingrediente-active\/cefoxitina\/\",\"url\":\"https:\/\/www.humanitas.net\/ro\/wiki\/ingrediente-active\/cefoxitina\/\",\"name\":\"Cefoxitina - 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