Calciphylaxis is a serious, uncommon condition characterized by cellular death (necrosis) of the fat and skin tissues. It causes painful skin ulcers and may cause serious infections in the body that can lead to death. Individuals suffering from this condition usually have kidney failure, are on dialysis or have recently had a kidney transplant.  



Possible signs and symptoms of calciphylaxis may include:

  • Calcification of skin blood vessels
  • Ischemic skin muscle lesions
  • Skin necrosis



The cause for calciphylaxis is unknown. It does not seem to be an immune type reaction (allergic reaction) and may not be restricted only to patients with kidney failure. Additional factors are involved.


Risk factors

Factors associated with an increased risk of calciphylaxis include:

  • Being overweight
  • Being a female
  • Being of Caucasian race
  • Diabetes
  • Hypoalbuminemia



Different treatments for calciphlaxis may include:

  • Continuous balance and control of phosphate and calcium levels
  • Dialysis
  • Intensive wound care
  • Immunosuppression
  • Pain control