Amphotericin B is used to treat progressive and potentially fatal fungal infections. It is also used to treat certain infections caused by protozoa (in particular, leishmaniasis).


What is Amphotericin B?

Amphotericin B acts by inhibiting the reproduction of fungi and killing them.


How should Amphotericin B be taken?

Amphotericin B is typically administered directly into the vein. The dosage varies from case to case.


Side effects associated with Amphotericin B

Among the possible side effects of Amphotericin B include the following:


  • Chills
  • Fever
  • Headache
  • Loss of appetite
  • Muscle or joint aches
  • Nausea
  • Stomach ache
  • Weight loss


It is important to contact a doctor immediately if you experience:


  • Rash
  • Uritcaria
  • Itch
  • Difficulty breathing
  • Tightness in chest
  • Swelling of the mouth, face, lips, or tongue
  • Chest pains
  • Convulsions
  • Dark or bloody stools
  • Decreased urination
  • Diarrhea
  • Dizziness
  • Rapid breathing
  • Hearing loss
  • Irregular heartbeat
  • Pain or redness at the injection site
  • Tiredness or weakness
  • Vomiting
  • Jaundice


Contraindications and warnings associated with the use of Amphotericin B

Amphotericin B may impair the ability to drive or operate hazardous machinery. This side effect can also be aggravated by other medications or alcohol.


During treatment, a doctor may prescribe other medications prior to Amphotericin B in order to reduce its possible side effects. The therapy must be completed correctly in order to ensure maximum effectiveness. This in turn will help to reduce the risk of developing resistance to other antifungal drugs.



Before starting treatment with Amphotericin B, it is important to tell your doctor if:


  • You have any allergies to the active substance, its excipients or any other drugs or food
  • You are taking any other medications, herbal remedies or supplements. Mentioning in particular:  azole antifungals, aminoglycosides, antineoplastic drugs, cyclosporine, pentamidine, corticosteroids, corticotropin, digoxin, flucytosine or muscle relaxants
  • You are suffering (or have suffered) from kidney problems
  • You are pregnant or breast-feeding