Apibaxan is used to reduce the risk of stroke and the formation of blood clots in individuals who suffer from atrial fibrillation. It is also used to prevent blood clots in individuals undergoing hip or knee surgery.  


What is Apibaxan?

Apibaxan is a direct factor Xa inhibitor. It works by preventing the blood from clotting.


How should Apibaxan be taken?

Apibaxan is administered orally in the form of tablets.


Side effects associated with Apibaxan

Apibaxan increases the risk of severe bleeding.


It is important to contact a doctor immediately if you experience:


  • Rash
  • Urticaria
  • Itch
  • Difficulty breathing
  • Tightness or chest pain
  • Swelling of the mouth, face, lips or tongue
  • Wheezing
  • Blood in the stool or sputum
  • Dark stools
  • Pain, swelling, or new wounds
  • Pink, red or brown urine
  • Joint pain or stiffness
  • Anemia
  • Symptoms of cerebral hemorrhage
  • Low blood pressure
  • Excessive sweating
  • Bruising or bleeding (including abnormal menstrual bleeding)
  • Vomiting that looks like coffee
  • Jaundice


Contraindications and warnings associated with the use of Apibaxan

Apibaxan is contraindicated in cases involving bleeding, severe liver problems and in the presence of artificial heart valves. It should also not be taken in combination with carbamazepine, phenytoin, rifampin , or St. John's wort.


Before starting treatment with Apibaxan, it is important to tell your doctor if:


  • You have any allergies to the active substance, its excipients or to any other drugs or food
  • You are taking any other medications, herbal remedies or supplements. Mentioning in particular: abciximab, alteplase, other anticoagulants, aspirin, bivalirudin, dabigatran, desirudin, eptifibatide, NSAIDs, platelet inhibitors, SSRIs, SNRIs, tirofiban, azole antifungals, clarithromycin, cobicistat, erythromycin, mifepristone, nefazodone, protease inhibitors, telithromycin, carbamazepine, ezalutamide, hydantoins, phenobarbital, rifamycins and hypericum
  • You are suffering (or have suffered) from bleeding disorders, bleeding problems, high blood pressure, blood vessel disorders, anemia or other blood disorders, platelet problems, gastrointestinal ulcers, stroke, liver or kidney disease or heart infections
  • You are at an increased risk of bleeding
  • You are planning on undergoing any surgical or dental procedures
  • You are pregnant or breast-feeding


Treatment should never be stopped without consulting with a doctor first.


It is important to inform physicians, surgeons and dentists of any ongoing treatment with apibaxan.