Bepridil is prescribed in the case of angina pectoris associated with coronary heart disease. Given that it can induce heartbeat abnormalities, its use is restricted only to cases where other drugs that would normally be used are not effective.


What is Bepridil?

Bepridil is an amine calcium channel blocker. It works by stopping the action of the channels that transport calcium into cells. In this way, it partially counteracts the increase of the calcium levels inside the cardiac muscle cells, thus reducing the force with which the heart beats. As a result, the heart needs less oxygen to work and angina pectoris (pain in the heart) is prevented.


How should Bepridil be taken?

Bepridil is administered orally, usually in the form of tablets to be taken once a day. In case of nausea, it can be taken with meals or before going to sleep.


Side effects associated with Bepridil

Bepridil can cause serious arrhythmias, especially in case of QT prolongation or low concentration of potassium or magnesium in the blood. It can also speed up or slow down the heart rate or cause other abnormalities.


Among the other possible side effects of Bepridil include the following:


  • Flu-like symptoms
  • Muscle aches
  • Fever
  • Nausea
  • Vomiting
  • Loss of appetite
  • Constipation
  • Gas
  • Dry mouth
  • Diarrhea
  • Headache
  • Fatigue
  • Nervousness
  • Drowsiness
  • Dizziness
  • Depression
  • Insomnia
  • Vision problems
  • Impotence
  • Sexual problems


Contraindications and warnings associated with the use of Bepridil

Before starting treatment with bepridil, it is important to tell your doctor if:


  • You have any allergies to the active substance, its excipients or any other drugs or food
  • You are taking any other medications, herbal remedies or supplements. Mentioning in particular:  quinidine, procainamide, disopyramide, flecainide, verapamil, diltiazem, beta blockers, tricyclic antidepressants, amitriptyline, digoxin and diuretics
  • You are suffering (or have suffered) from any diseases
  • You are pregnant or breastfeeding