Bretylium inhibits the release of norepinephrine. Its mechanisms of action have not yet been clarified but it is thought to act by inhibiting the channels present on the membranes of nerve cells and the activity of certain enzymes. The result is an anti-arrhythmic effect and antifibrillatory effect on the heart.
What is Bretylium?
Bretylium is used in emergency situations to handle ventricular tachycardia. In the case of ventricular fibrillation, it is applied both as a treatment or prophylaxis.
How should Bretylium be taken?
Bretylium can be taken via injection or intramuscularly. The administration can only be performed by medical staff and it is reserved for emergencies.
Side effects associated with Bretylium
Dizziness, light headedness and clamminess are the most common side effects associated with administration of Bretylium.
Other possible problems associated with its use include the following:
- Increased frequency of premature ventricular contractions
- Mild conjunctivitis
- Kidney dysfunction
- Abdominal pains
- Shortness of breath
- Increased arrhythmias
- Emotional instability
- Transient hypertension
- Postural hypotension
- Stuffy nose
- Feeling of pressure in the sternum
- Widespread physical sensitivity
Contraindications and warnings associated with the use of Bretylium
Before taking Bretylium, it is important to inform your doctor:
- If you have any drug allergies
- If you are taking any medications, herbal remedies or supplements. You should mention in particular: cisapride, clarithromycin, erythromycin, gatifloxacin, grepafloxacin, levofloxacin, thioridazine and moxifloxacin, ranolazine, telithromycin, thioridazine and digitalis glycosides
- If you suffer from aortic stenosis, severe pulmonary hypertension or other cardiovascular problems