Cabazitaxel is used in combination with prednisone to treat some forms of prostate cancer.


What is Cabazitaxel?

Cabazitaxel works by blocking the cell cycle. By doing so, it blocks the proliferation of tumors.


How should Cabazitaxel be taken?

Cabazitaxel is administered by the doctor intravenously via injection.


Side effects associated with Cabazitaxel

Cabazitaxel can reduce your ability to fight infections.


Among the other possible side effects of Cabazitaxel include the following:


  • Back ache
  • Constipation
  • Diarrhea
  • Dizziness
  • Hair loss
  • Digestive problems
  • Articular pains
  • Loss of appetite
  • Mild pain, redness or swelling at the injection site
  • Mild weight loss
  • Muscle spasms
  • Nausea
  • Numbness, tingling, burning or decreased sensitivity of the hands or feet
  • Stomach ache
  • Changes in taste
  • Vomiting
  • Tiredness or weakness


It is important to contact a doctor immediately if you experience:


  • Rash
  • Urticaria
  • Itch
  • Difficulty breathing
  • Pain or tightness in the chest
  • Swelling of the mouth, face, lips or tongue
  • Bloody stool
  • Stool color changes
  • Fainting
  • Slow, fast or irregular heartbeat
  • Mouth sores or inflammation
  • Severe or persistent dizziness or headache
  • Severe and continuous weight loss
  • Shortness of breath
  • Symptoms of a brain hemorrhage ( confusion, weakness in one side of body, vision problems, slurred speech)
  • Fever, chills, sore throat, cough, increased urination or painful urination, muscle pain, swollen glands
  • Bruising or bleeding
  • Wheezing


Contraindications and warnings associated with the use of Cabazitaxel

Cabazitaxel should not be taken in case of liver problems or low levels of neutrophils. It may impair the ability to drive or operate hazardous machinery, especially if taken in combination with alcohol or other drugs. During treatment with Cabazitaxel, it is advisable not to receive live vaccines.


Before starting treatment with Cabazitaxel, it is important to tell your doctor if:


  • You have any allergies to the active substance, its excipients or other drugs (particularly those containing polysorbate 80) or food
  • You are taking any other medications, herbal remedies or supplements. Mentioning in particular:  anticoagulants, azole antifungals, cobicistat, macrolide antibiotics, mifepristone, nefazodone, protease inhibitors, telithromycin, barbiturates, bosentan, carbamazepine, dexamethasone, efavirenz, enzalutamide, felbamate, griseofulvin, hydantoins , modanafil, nevirapine, oxcarbazepine, primidone, rifamycins, St. John's wort, topiramate and palifermin
  • You are taking (or have taken) steroids
  • You are suffering (or have suffered) from kidney or liver problems, gastrointestinal problems, long-term or recurring infections, bone marrow problems, low levels of white blood cells, malnutrition, dehydration or a weakened immune system
  • You are undergoing (or have undergone) radiation to the abdomen or pelvis


It is important to inform physicians, surgeons and dentists of any ongoing treatment with Cabazitaxel.