Carbexonolone is primarily used to treat gastrointestinal ulcers, especially those located in the stomach. It is also used to treat peptic esophagitis and the presence of canker sores in the oral cavity.


What is Carbenoxolone?

Carbenoxolone is a glycrrhetinic acid derivative found in the root of the licorice plant.  It promotes healing of gastric and duodenal ulcers through its strong anti-inflammatory action. Its exact mechanism of action has not yet been identified.


How should Carbenoxolone be taken?

Carbexonolone is administered by oral route or by inhalation.


Side effects associated with Carbenoxolone

Carbenoxolone may exercise an antidiuretic effect. It can also reduce potassium levels in the blood, cause fluid retention and increase blood pressure.


Among the other possible side effects of carbenoxolone include the following:


  • Headache
  • Weight gain


It is important to contact a doctor immediately if you experience:


  • Rash
  • Urticaria
  • Difficulty breathing
  • Tightness in the chest
  • Swelling of the mouth, face, lips or tongue
  • Hypokalemia
  • Hypertension
  • Heart failure
  • Papilledema


Contraindications and warnings associated with the use of Carbenoxolone

Before starting treatment with carbenoxolone, it is important to tell your doctor if:


  • You have any allergies to the active substance, its excipients, or to any other drugs, food and various substances
  • You are taking any other medications, herbal remedies or supplements. Mentioning in particular: aluminum hydroxide, amiloride, bendrofluazide, canrenoate, clorotiazidem chlorthalidone, clopamide, deflazacort, diazoxide, digitoxin, digoxin, hydrochlorothiazide, lactitol monohydrate, lofexidine, metirosine, perindopril, piretanide and spironolactone
  • You are suffering (or have suffered) from hypertension, heart failure, lack of potassium in the blood, heart disease, kidney or liver disease
  • You are pregnant or breast-feeding