Carbidopa is a substance inhibiting a mechanism known as "dopa-decarboxylase device". By itself it has antihypertensive properties and it is used in combination with levodopa in the treatment of Parkinson's disease. It is administered together with levodopa because by inhibiting the molecule that inhibits dopa decarboxylase device it blocks the conversion of levodopa into dopamine allowing the latter to exert its action on the central nervous system. The carbidopa is not able to cross the blood brain barrier.


What is Carbidopa?


By itself, Carbidopa has antihypertensive properties, but it is used in combination with levodopa for the treatment of Parkinson's disease.


How should Carbidopa be taken?


The Carbidopa is taken orally, in the form of tablets, usually in combination with levodopa. The medications should be consumed during meals.


Side effects associated with Carbidopa


In general, Carbidopa is well tolerated; the side effects , for most of the time, depend on the drugs that are taken in combination with it (such as Levodopa, for example).


In the assumption of Carbidopa/Levodopa formulation the following adverse effects may occur:


  • Worsening of involuntary movements of the muscles
  • Mood changes
  • Confusion
  • Depression
  • Hallucinations
  • Dizziness
  • Nausea
  • Vomiting
  • Drowsiness


Some of the very rare side effects – but more severe – may include:


  • Easy bleeding
  • Infections of various types (fever, persistent sore throat),
  • Tingling in the hands and/or feet
  • Visual disturbances (blurred vision, double vision)
  • Chest pain
  • Convulsions
  • Allergic reactions (rash, itching, swelling of face-tongue-throat, trouble breathing) are possible but very unlikely.


Contraindications and warnings associated with the use of Carbidopa


It is recommended not to drink alcohol during therapy with this drug, as it may increase certain side effects such as drowsiness.

Particular attention should be paid when administering this drug to patients with a history of hypersensitivity to the active substance or other drugs. Moreover, take caution when administrating this drug in patients with respiratory problems (asthma, emphysema), glaucoma, heart or blood vessel problems, kidney disease, liver disease, peptic ulcer disease, and sleep disorders.

In pregnant and lactating women the drug can only be used if clearly and strictly necessary, and based upon the doctor’s medical opinion and instructions.