Clobazam is used to treat certain types of seizures, particularly those associated with Lennox-Gastaut syndrome.


What is Clobazam?

Clobazam is a benzodiazepine. Its exact mechanism of action has not yet been identified. It is thought to involve the action of a certain chemical known gamma-aminobutyric acid (GABA).


How should Clobazam be taken?

Clobazam is administered orally.


Side effects associated with Clobazam

Clobazam may increase the risk of suicidal behavior, particularly in patients who are already at risk. It can also be associated with toxic epidermal necrolysis and it may reduce the effectiveness of hormonal contraceptives.


Among the other possible side effects of Clobazam include the following:  


  • Constipation
  • Drooling
  • Drowsiness
  • Indolence
  • Fatigue
  • Vomiting


It is important to contact a doctor immediately if you experience:


  • Rash
  • Urticaria
  • Itch
  • Difficulty breathing
  • Tightness in the chest
  • Swelling of the mouth, face, lips, throat or tongue
  • Changes in appetite
  • Confusion
  • Loss of coordination
  • Difficult or painful urination
  • Persistent fever, chills, sore throat or cough
  • Hallucinations
  • New psychological or mood problems or worsening of existing ones
  • Shortness of breath
  • Difficulty speaking
  • Suicidal thoughts
  • Insomnia
  • Difficulty swallowing
  • Bleeding or bruising
  • Unusual tiredness or weakness
  • Vision problems


Contraindications and warnings associated with the use of Clobazam

Before starting treatment with clobazam, it is important to tell your doctor if:


  • You have any allergies to the active substance, its excipients, or to any other drugs, food and various substances
  • You are taking any other medications, herbal remedies or supplements. Mentioning in particular: opioid analgesics, other benzodiazepines, tricyclic antidepressants, fluconazole, fluvoxamine, omeprazole or ticlopidine
  • You are suffering (or have suffered) from glaucoma, increased pressure in the eye, liver or kidney problems, myasthenia gravis, porphyria, lung or breathing problems or psychological disorders
  • You are experiencing (or have experienced) suicidal thoughts
  • You are suffering (or have suffered) from alcohol or substance abuse  
  • You are pregnant or breast-feeding


Treatment with clobazam should not be stopped abruptly without first consulting with a doctor. This is because possible side effects, such as seizures, may be triggered.


The drug may impair the ability to drive or operate hazardous machinery. This side effect may be aggravated by alcohol and certain other medications.


It is important to inform physicians, surgeons and dentists of any ongoing treatment with clobazam.