Clorprompramide is used to manage type 2 diabetes in patients who cannot control the levels of blood sugar through a combination of diet and physical activity. Nevertheless, it must be taken within a feeding program and appropriate exercise.


What is Clorpropramide?


Clorpropramide is an antidiabetic agent that acts by promoting the release of insulin from the pancreas. In this way it helps to reduce the levels of blood sugar.


How should Clorpropramide be taken?


Clorpropramide is administered orally in the form of tablets. It can be taken alone or in combination with other anti-diabetic drugs.


Side effects associated with Clorpropramide


Clorpropramide can lead to hypoglycemia, especially following prolonged physical activity, if you are taking alcohol or when you skip meals. It can also increase the risk of death due to heart disease and increase the skin's sensitivity to the sun.


Among the other possible adverse effects are included:


  • Dizziness
  • Headache
  • Nausea


You should immediately contact a doctor if taking Clorpropramide triggers any of the following symptoms:


  • Rash
  • Urticaria
  • Itching
  • Difficulty breathing
  • Tightness in the chest
  • Swelling of the mouth, face, lips, or tongue
  • Confusion
  • Dark urine
  • Fever, chills or persistent sore throat
  • Irregular heartbeat
  • Hypoglycemia (anxiety, drowsiness, irregular heartbeat, feeling faint, dizziness or severe or persistent headaches, tremors, unusual sweating, weakness)
  • Severe or persistent vision problems
  • Bruising or bleeding
  • Excessive tiredness or weakness
  • Jaundice


Contraindications and warnings associated with the use of Clorpropramide


Clorpropramide should not be taken in case of diabetic ketoacidosis or diabetic coma, in cases of type 1 diabetes, acidosis or moderate to severe burns or severe liver, kidney, thyroid or endocrinological problems.


Clorpropramide can compromise the ability to drive or operate hazardous machinery, especially when taken together with alcohol or other medicines that may cause drowsiness. Moreover, the simultaneous intake of alcohol increases the risk of hypoglycemia.


Before you start treatment with Clorpropramide it is important to tell your doctor if:


  • You have any allergies to the active substance, its excipients or other drugs (in particular sulfonamides, celecoxib, diuretics, glipizide, probenecid, sulfamethoxazole, valdecoxib or zonisamide) or food
  • You are taking other medications, herbal remedies and supplements, citing in particular beta blockers, ACE inhibitors, anticoagulants, anti-fungal azolicim chloramphenicol, clofibrate, fenfluramine, insulin, MAO inhibitors, NSAIDs, fenilbutazopne, probenecid, quinolones, salicylates, sulfonamides, acidifying urine agents, calcium antagonists, corticosteroids, decongestants, diazoxide, diuretics, estrogen, hormonal contraceptives, isoniazid, niacin, fenotiazione, phenytoin, rifamycins, sympathomimetic, thyroid medication, gemfibrozil and barbiturates
  • You suffer (or have suffered) from liver, kidney, gastrointestinal, thyroid or heart problems, high fever, severe infections or diarrhea, high acid levels in the blood, severe trauma, blood or hormonal problems, low sodium levels blood deficiency G6PDH or syndrome of inappropriate secretion of antidiuretic hormone (ADH)
  • You drink alcohol
  • You are planning a surgery
  • You are pregnant or breastfeeding


Lastly, it is recommended to inform doctors, dentists and surgeons about ongoing treatment with Clorpropramide prior to any procedure.