Colistimethate is used to treat Gram-negative aerobic bacteria infections. It is particularly recommended against infections caused by strains of Pseudomonas aeruginosa sensitive to its action.


What is Colistimethate?

Colistimethate penetrates the bacterial membrane, thus destroying it and killing off the microbes.


How should Colistimethate be taken?

Colistimethate is administered intramuscularly via injection or intravenously via infusion.


Side effects associated with Colistimethate

Prolonged or repetitive use of colistimethate may cause a second infection.


Among the other possible side effects of colistimethate include the following:


  • Strange skin sensations around the mouth
  • Dizziness
  • Itch
  • Numbness or tingling in the fingers
  • Difficulty speaking
  • Stomach discomfort


It is important to contact a doctor immediately if you experience:


  • Rash
  • Urticaria
  • Itch
  • Difficulty breathing
  • Tightness in the chest
  • Swelling of the mouth, face, lips or tongue
  • Dark or bloody stools
  • Decreased urination
  • Fever
  • Severe diarrhea
  • Shortness of breath
  • Stomach pain or cramps


Contraindications and warnings associated with the use of Colistimethate

Colistimethate may be contraindicated in case of cephalothin intake.


 Before starting treatment with Colistimethate, it is important to tell your doctor if:


  • You have any allergies to the active substance, its excipients, or to any other drugs, food and various substances
  • You are taking any other medications, herbal remedies or supplements. Mentioning in particular: cephalothin, aminoglycosides, muscle relaxants, polymyxin, sodium citrate, or succinylcholine
  • You are suffering (or have suffered) from kidney problems
  • You are pregnant or breast-feeding


It is important to inform physicians, surgeons and dentists of any ongoing treatment with colistimethate.


The drug can compromise the ability to drive or operate hazardous machinery. This side effect can be exacerbated by alcohol and certain other medications.