Cycloserine is used primarily as an anti-tuberculosis agent and secondary when the first choice drugs are ineffective or when their use is precluded for various reasons (intolerance or presence of resistant organisms). It is able to act in general against Gram-positive and Gram-negative bacteria, and in particular on tuberculous mycobacteria such as Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium bovis and other atypical bacteria. It is also used in the treatment of urinary tract infections that do not respond to other therapies.


What is Cycloserine?


Cycloserine is an antimicrobial broad spectrum substance isolated from Streptomyces orchidaceus (fungal species) and produced by synthesis. The antibacterial action of the drug is inhibition of cell wall synthesis of bacteria (in particular for competing with D-alanine, a precursor of a component of bacterial cell wall).


How should Cycloserine be taken?


Cycloserine is taken orally.


Side effects associated with Cycloserine


There are several side effects caused by use of Cycloserine. Some of the most common side effects include central nervous system disorders (convulsions, headache, psychosis, paresis, hyperreflexia, paresthesias), increased transaminases and allergic reactions.


Contraindications and warnings associated with the use of Cycloserine


Since Cycloserine is able to cross the blood-brain barrier and appears to be characterized by high toxicity, its use is rather rare.