Diflunisal is a non-steroidal anti-inflammatory drug (NSAID). It works by blocking the production of molecules at the base of the appearance of pain, fever and inflammation.


What is Diflunisal?

Diflunisal is used to treat pain and sensitivity and stiffness caused by arthritis and rheumatoid arthritis. It can be also used to treat mild, moderate and intense pain of different origin.


How should Diflunisal be taken?

Typically, diflunisal should be taken every 8-12 hours in the form of oral tablets to be swallowed (strictly whole) with water, milk or food.

The benefits of its administration may be seen only after several days. 


Side effects associated with Diflunisal

Possible side effects of diflunisal include the following:

  • Vomiting
  • Diarrhea
  • Constipation
  • Gas
  • Headache
  • Dizziness
  • Tinnitus
  • Vision problems


It is important to contact a doctor immediately if the intake of the drug triggers:

  • Gastric disorders
  • Excessive fatigue
  • Itching
  • Lack of energy
  • Loss of appetite
  • Pain in the right upper abdomen
  • Jaundice
  • Flu-like symptoms
  • Rash
  • Blisters
  • Fever or chills
  • Pallor
  • Rapid heartbeat
  • Bruising or bleeding
  • Muscle or joint pain
  • Unjustified loss of weight
  • Backache
  • Unclear urine , colorless or bloody
  • Difficult or painful urination
  • Frequent need to urinate, especially at night
  • Swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles or calves
  • Hoarseness
  • Difficulty swallowing or breathing


Contraindications and warnings associated with the use of Diflunisal

The intake of NSAIDs (diflunisal included) can increase the risk of heart attack and stroke. It can also be associated with ulcers, bleeding and perforations in the wall of the stomach or intestines. The drug should not be administered if you are experiencing an ongoing viral infection.


Before intake, it is important to inform your doctor:

  • If you have any allergies to the active substance or to any other NSAIDs / aspirin
  • If you are taking any medicinal products or herbal supplements. Mentioning in particular: ibuprofen, ACE inhibitors, receptor antagonists, Angiotensin II, diuretics, indomethacin, lithium, methotrexate and sulindac
  • If you are suffering (or have suffered) from swelling of the hands, feet, ankles or calves or kidney disease
  • If you are suffering (or have suffered) from any liver problems, or asthma (especially in case of frequent indoor nose problems or polyps)
  • If you suspect a viral infection (and influenza)
  • If you are pregnant or breast-feeding