Dinoprostone is used to prepare the cervix for the induction of labor.


What is Dinoprostone?


Dinoprostone stimulates contraction of the uterine muscles. Its exact mechanism of action is unknown, but it is thought to exert a direct stimulation of the myometrium, the muscle layer of the uterine wall.


In addition, Dinoprostone seems to act more at the level of the uterine cervix effects, including its expansion. Even in this case, its exact mechanism of action is unknown, but it is believed that it is related to the degradation of collagen after the secretion of the enzyme collagenase stimulated by the administration of the drug.


How should Dinoprostone be taken?


Dinoprostone is administered by medical staff using a syringe that is inserted into the vagina. In case of need, the administration can be repeated at a six-hour distance.


Side effects associated with Dinoprostone


Among the possible adverse effects of Dinoprostone are included:


  • Stomach discomfort
  • Vomiting
  • Diarrhea
  • Dizziness
  • Skin redness
  • Headache
  • Fever


You should immediately contact your doctor if Dinoprostone triggers any of the following symptoms:


  • Vaginal discharge, especially if it increases in the days following administration
  • Persistent fever
  • Chills
  • Pain or tightness in the chest;
  • Skin rash
  • Urticaria
  • Difficulty breathing
  • Swelling of the face


Contraindications and warnings associated with the use of Dinoprostone


Before administration of Dinoprostone it is important to tell your doctor if:


  • You have any allergies to the active substance , to other components or to other drugs or foods
  • You are taking other medications, herbal remedies and supplements
  • You suffer (or have suffered) from asthma, anemia, diabetes, high or low blood pressure, placenta previa, seizures, glaucoma or increased intraocular pressure, unexpected vaginal bleeding or kidney, liver or heart disease
  • You are suffering from cephalo-pelvic disproportion
  • You have ever undergone a cesarean or other uterine surgery
  • You have other children
  • You have had previous deliveries that were difficult or traumatic