Leucovorin is used to reduce the toxic effects of methotrexate and other medications (folic acid antagonists).


What is Leucovorin?

Leucovorin is a folic acid derivative (Vitamin B9). It acts by replacing folate in the body that is lost due to certain folic acid antagonists.


How should Leucovorin be taken?

Leucovorin can be administered orally or intravenously via injection.


Side effects associated with Leucovorin

Leucovorin is not associated with any specific side effects. It is, however, important to contact a doctor immediately if you experience:


  • Rash
  • Urticaria
  • Difficulty breathing
  • Tightness in the chest
  • Swelling of the mouth, face, lips or tongue
  • Fainting
  • Convulsions


Contraindications and warnings associated with the use of Leucovorin

Before starting treatment with Leucovorin, it is important to tell your doctor if:


  • You have any allergies to the active substance, its excipients or any other drugs or food
  • You are taking any other medications, herbal remedies or supplements. Mentioning in particular:  fluorouracil, trimethoprim, sulfamethoxazole, phenobarbital, phenytoin and primidone
  • You are suffering (or have suffered) from pernicious anemia or other types of anemia due to low levels of vitamin B12 in the blood
  • You are pregnant or breast-feeding