Medroxyprogesterone is progestin. It works by blocking the thickening of the wall of the uterus and stimulating the production of hormones by the same uterus.


What is Medroxyprogesterone?

Medroxyprogesterone is used in cases involving menstrual problems or irregular bleeding. It can also be used to stimulate a normal menstrual cycle in women whose cycle has been irregular for at least 6 months, though not as a result of pregnancy or menopause. Lastly, it can be used to prevent thickening of the wall of the uterus and reduce the risk of cancer in patients taking estrogen.


How should Medroxyprogesterone be taken?

Medroxyprogesterone is taken in the form of tablets, usually 1 time per day and on certain days of the month.


Side effects associated with Medroxyprogesterone

Possible side effects of Medroxyprogesterone include the following:

  • Acne
  • Alopecia
  • Changes in menstrual flow
  • Breast pain and discharge from the nipple
  • Stomach discomfort
  • Insomnia
  • Hirsutism
  • Drowsiness
  • Spotting or irregular cycle
  • Weight changes


You should immediately contact a doctor if taking the drug triggers:

  • Fast or pounding heartbeat
  • Dizziness or fainting
  • Skipped menstrual cycle
  • Weakness or numbness in a leg or an arm
  • Depression
  • Difficulty speaking
  • Difficulty breathing  or difficulty swallowing
  • Chest pain that is sudden and sharp or violent
  • Pain, swelling, overheating, redness or tenderness to the touch in the leg
  • Fever
  • Shortness of breath
  • Swollen hands, feet, ankles or calves
  • Jaundice
  • Protruding eyes
  • Urticaria
  • Vision problems
  • Itch
  • Skin rash
  • Blood in the sputum

Contraindications and warnings associated with the use of Medroxyprogesterone

Before taking Medroxyprogesterone, it is important to inform your doctor: 

  • If you have any allergies to the active substances, any other medication or corn
  • If you are taking any medicines, herbal supplements and other drugs. Mentioning in particular: aminoglutethimide
  • If you suffer (or if you have suffered) from breast cancer or any other cancer of the female organs, as well as abnormal vaginal bleeding, a missed abortion, blood clots, stroke or mini-stroke, seizures, migraine, depression, asthma, diabetes or heart disease, kidney or liver disease
  • If you are pregnant or breast-feeding


In any case, it is important to inform surgeons or dentists of any ongoing treatment with Medroxyprogesterone.