Methysergide is used to prevent or reduce the frequency and pain of some severe forms of headaches (e.g. migraine and cluster headaches). It is only used in cases where other treatments have not been effective. Methysergide is not indicated for the treatment of an ongoing migraine attack.


What is Methysergide?

Methysergide is an ergot derivative. It is believed to be involved in narrowing the blood vessels in the head, thus reducing pain.


How should Methysergide be taken?

Methysergide is typically administered orally with food.  A doctor may initially prescribe a lower dose and then gradually increase it if necessary. In any case, 2-3 dosages per day should not be exceeded.


Side effects associated with Methysergide

Although rare, when the use of Methysergide is prolonged, it can cause thickening of the heart valves, lining of the lungs and abdominal cavity.


Among the other possible side effects of Methysergide include the following:


  • Nausea
  • Vomiting
  • Diarrhea
  • Dizziness
  • Drowsiness
  • Stomach problems
  • Heartburn
  • Insomnia
  • Redness


You should contact a doctor immediately if you experience:


  • Chest pains
  • Difficulty breathing
  • Back ache
  • Difficulty passing urine
  • Urine with an unusual color
  • Unusual tiredness
  • Numbness or tingling in hands or feet
  • Rapid heartbeat
  • Pallor or cyanosis of the hands or fingers
  • Strong muscle weakness
  • Weight gain
  • Severe dizziness (especially while standing)
  • Vision problems
  • Confusion
  • Difficulty speaking
  • Rash
  • Itch
  • Swelling of face, lips, tongue or throat


Contraindications and warnings associated with the use of Methysergide

Methysergide can compromise the ability to drive or operate hazardous machinery.


Before starting treatment with Methysergide, it is important to tell your doctor if:


  • You have any allergies to the active substance, its excipients or any other drugs (especially other ergot derivatives) or food
  • You are taking any other medications, herbal remedies or supplements
  • You are suffering (or have suffered) from autoimmune diseases, blood vessel disease, uncontrolled high blood pressure, cardiovascular diseases, severe infections, diabetes, hypertension, gastrointestinal ulcers, fibrosis due to taking medication, severe liver problems, lung or kidney disease, migraine, malnutrition or urinary tract obstruction
  • You are pregnant or breast-feeding