Phentolamine is used to treat hypertension, pheochromocytoma, Raynaud's syndrome (vasospasm and freezing fingers syndrome), clonidine withdrawal syndrome, impotence and peripheral vascular disease.


What is Phentolamine?

Phentolamine interacts with so-called alpha-adrenergic receptors, thus causing muscle relaxation and dilation of the blood vessels. This in turn leads to low blood pressure. Phentolamine also increases cardiac output by stimulating other beta-adrenergic receptors.


How should Phentolamine be taken?

Phentolamine can be administered intramuscularly via injections or intravenously.


Side effects associated with Phentolamine

Among the possible side effects of phentolamine include the following:


  • Swelling, bruising or bleeding at the injection site
  • Penile burning sensation
  • Difficulty with ejaculation


It is important to contact a doctor right away if you experience:


  • Dizziness
  • Painful erection that lasts for more than 4 hours
  • Bumps on the penis


Contraindications and warnings associated with the use of Phentolamine

Before taking Phentolamine, it is important to tell your doctor if:


  • You have any allergies to the active substance, its excipients or any other drugs
  • You are taking any other medications, herbal remedies or supplements. Mentioning in particular:  tadalafil , tamsulosin , treprostinil and vardenafil
  • You are suffering (or have suffered) from a particular disease or health problems (particularly  myocardial infarction, coronary insufficiency, angina or other cardiovascular disorders)
  • You are pregnant or breastfeeding