Pramipexole is used to treat the symptoms of Parkinson's disease and those of restless legs syndrome.


What is Pramipexole?


Pramipexole interferes with the activity of the neurotransmitter dopamine. Its exact mechanism of action is not fully understood, but it is thought that it could enhance the function of certain receptors in the brain.


How should Pramipexole be taken?


Pramipexole is administered orally. In case of nausea, intake with food may reduce the annoying side effect.


Side effects associated with Pramipexole


The possible adverse effects of Pramipexole may include:


  • Unusual dreams
  • Constipation
  • Diarrhea
  • Dizziness
  • Drowsiness
  • Dry mouth
  • Headache
  • Loss of appetite
  • Nausea
  • Stuffy nose
  • Fatigue
  • Sleep disorders
  • Weakness


It is important to contact a doctor immediately if taking Pramipexole triggers any of the following symptoms:


  • Rash
  • Itching
  • Swelling of face, eyes, lips, tongue or throat
  • Difficulty breathing
  • Tightness or chest pain
  • Unusual thoughts
  • Problems with balance
  • Physical disabilities
  • Variations in the amount of urine produced
  • Dark urine
  • Confusion
  • Problems in the sexual sphere
  • Fainting
  • Hallucinations
  • Memory problems
  • Pain, weakness or sensitivity to the muscles
  • Changes in the appearance of a mole or the appearance of new skin formations
  • Psychological problems, mood disorders or behavioral problems
  • Strong or persistent dizziness or drowsiness
  • Shortness of breath
  • Sudden urge to sleep at unusual hours
  • Sudden weight loss
  • Swelling of the hands, legs or feet
  • Difficulty swallowing
  • Vision problems


Contraindications and warnings associated with the use of Pramipexole


Pramipexole may impair the ability to drive or operate hazardous machinery. This side effect can be aggravated by alcohol or taking other medicines. Besides alcohol, hot weather, exercise, and fever, it can increase dizziness caused by the medication; therefore, it is recommended to be careful when getting up quickly from a lying or sitting position, especially in the morning.


Before taking Pramipexole it is important to tell your doctor if:


  • You have any allergies to the active substance, its excipients, other medicines, foods, or any other substance
  • You are taking other medications, herbal remedies and supplements, in particular cimetidine, butyrophenones, metoclopramide, phenothiazines, thioxanthenes and levodopa
  • You suffer (or have suffered) from kidney problems, low blood pressure, dizziness or fainting when getting up from lying or sitting position, sleep disturbances, difficulty controlling the muscles, psychological problems, mood disorders or behavioral problems (including compulsive behaviors)
  • You are drinking alcohol
  • You are pregnant or breastfeeding


Lastly, it is important to inform physicians, surgeons and dentists about ongoing treatment with Pramipexole prior to any procedure.