Primaquine is used to prevent relapse of a type of malaria caused by Plasmodium vivax.


What is Primaquine?


Primaquine acts by preventing the development of blood forms of Plasmodium vivax, the parasite responsible for the so-called vivax malaria.


How should Primaquine be taken?


Primaquine is administered orally. In the event that the medications triggers stomach problems, it is advisable to take it with food to reduce stomach irritation.


Side effects associated with Primaquine


The possible adverse effects of Primaquine may include:


  • Nausea
  • Abdominal cramps
  • Stomach discomfort
  • Vomiting


It is important to contact a doctor immediately if taking Primaquine triggers any of the following symptoms:


  • Rash
  • Itching
  • Swelling of face, eyes, lips, tongue or throat
  • Difficulty breathing
  • Tightness in the chest
  • Dark urine
  • Dizziness
  • Fainting
  • Irregular or accelerated heartbeat
  • Fever or chills
  • Stomach or back ache
  • Fatigue or unusual weakness
  • Jaundice


Contraindications and warnings associated with the use of Primaquine


Primaquine is contraindicated in case of rheumatoid arthritis, systemic lupus erythematosus and certain blood disorders. It should also not be used in case of recent use of quinacrine or administration of drugs that can interfere with the activity of the bone marrow.

Moreover, before starting treatment it is important to tell your doctor if:


  • You have any allergies to the active substance, its excipients, other medicines, foods, or any other substance
  • You are taking other medications, herbal remedies and supplements, in particular quinacrine and drugs that may increase the risk of QT prolongation
  • You suffer (or have suffered) from G6PDH deficiency, favismo, NADH methemoglobin reductase deficiency, heart problems, low levels of potassium or magnesium in the blood
  • You are pregnant or breastfeeding


Lastly, it is also recommended to inform physicians, surgeons and dentists about ongoing treatment with Primaquine prior to any procedure.