The tacrine acts at the level of the central nervous system by inhibiting acetylcholinesterase in a reversible manner. Acetylcholinesterase is the enzyme that degrades the neurotransmitter at the base of the nerve impulse transmission mechanisms compromised in case of Alzheimer's (acetylcholine) disease. Its action improves cognitive symptoms associated with the disease.


What is Tacrine?


Tacrine is used to treat the symptoms of Alzheimer's disease.


How should Tacrine be taken?


The tacrine is commercially available the form of capsules for oral use. Typically, the dosage is 4 capsules a day, taken on an empty stomach (1 hour

before or 2 hours after meals).


The side effects associated with Tacrine


The potential adverse effects of tacrine may include:


  • Heartburn
  • Muscle aches
  • Stomach discomfort
  • Loss of appetite
  • Loss of balance
  • Vomiting
  • Diarrhea


It is important to immediately contact a doctor if taking tacrine triggers any of the following symptoms:


  • The color of the stool changes
  • Difficulty urinating
  • Jaundice
  • Stomach ache
  • Rash


Contraindications and warnings associated with the use of Tacrine


Prior to noticing appreciable benefits, tacrine should be taken regularly for a few weeks.


Before taking the medicine it is recommended to inform your doctor if:


  • You have any allergies to the active substance or other drugs
  • You are taking other medications, especially drugs similar to atropine, those for treating colds, sinusitis or allergies, bethanechol, cimetidine, NSAIDs, theophylline, anti-ulcer medications and supplements of vitamins
  • You are suffering (or have suffered) from ulcers, seizures, urinary problems, asthma, jaundice associated with the intake of tacrine, and cardiovascular, kidney, liver, lung or gastric disease
  • You are pregnant or breast-feeding


While undergoing treatment with tacrine, you must consider the risk of drowsiness while you are driving or if you operate dangerous machinery, as well as in the case of surgical or dental procedures, you must always alert doctors and dentists that you are being treated with tacrine.