Tolazamide is used in combination with diet and exercise to treat type 2 diabetes.


What is Tolazamide?


Tolazamide promotes the release of insulin from the pancreas. In this way, it helps control blood sugar levels in the blood.


How should Tolazamide be taken?


Tolazamide is administered orally, in the form of tablets, alone or in combination with other anti-diabetic agents.


Side effects associated with Tolazamide


Tolazamide can cause hypoglycemia, especially after an intense or prolonged exercise, if you skip meals or if you drink alcohol. It also can increase the risk of dying from cardiovascular disease and it can increase the skin's sensitivity to the sun.


Among the other possible adverse effects are included:


  • Feeling of having a full stomach
  • Nausea


It is important to immediately contact a doctor if taking Tolazamide triggers any of the following symptoms:


  • Rash
  • Urticaria
  • Itching
  • Difficulty breathing
  • Tightness in the chest
  • Swelling of the mouth, face, lips, or tongue
  • Redness
  • Dizziness
  • Confusion
  • Dark urine
  • Fainting
  • Fever, chills or persistent sore throat
  • Irregular heartbeat
  • Hypoglycemia
  • Vision problems
  • Bleeding or bruising
  • Fatigue or unusual weakness
  • Jaundice


Contraindications and warnings associated with the use of Tolazamide


Tolazamide is contraindicated in the presence of serious diabetes complications (such as diabetic ketoacidosis or diabetic coma), moderate to severe burns or acidosis.


Tolazamide may impair the ability to drive or operate hazardous machinery, especially when taken together with alcohol or other drugs. In addition, the dizziness associated with its intake can be aggravated by high temperatures, physical activity and fever.


Before taking Tolazamide it is important to tell your doctor if:


  • You have any allergies to the active substance, its excipients or other drugs (especially sulfa), substances or foods
  • You are taking other medications, herbal remedies and supplements, citing in particular beta blockers, ACE inhibitors, anticoagulants, azole antifungals, chloramphenicol, clofibrate, fenfluramine, insulin, MAO inhibitors, NSAIDs, phenylbutazone, probenecid, quinolones, salicylates, sulfa drugs, calcium channel blockers, corticosteroids , decongestants, diazoxide, diuretics, estrogen, hormonal contraceptives, isoniazid, niacin, phenothiazines, phenytoin, rifamycins, thyroid medications, and gemfibrozil
  • You suffer (or have suffered) from liver, renal, cardiac, gastrointestinal or thyroid disease, type 1 diabetes, severe infections, severe diarrhea, acidosis, severe trauma, hormonal problems or low sodium levels in the blood
  • You suffer from ill health
  • You suffer from high fever
  • You have planned a surgery
  • You drink alcohol
  • You suffer from malnutrition
  • You are pregnant or breastfeeding


Lastly, it is also recommended to inform physicians, surgeons and dentists about ongoing treatment with Tolazamide prior to any procedure.