Topiramate is an anticonvulsant that is used to prevent migraine attacks.


What is Topiramate?

Topiramate works by affecting several chemicals in the brain. In this way, it reduces seizure activity that leads to convulsions and prevents migraine attacks from occurring.


How should Topiramate be taken?

Topiramate is taken orally and in combination with plenty of fluids. In some cases, it can also be combined with other medications.  


Side effects associated with Topiramate

Topiramate can increase metabolic acidosis. It can also increase the levels of ammonia in the blood, reduce the effectiveness of birth control methods and trigger severe eye problems.


Among the other possible side effects of topiramate include the following:


  • Constipation
  • Diarrhea
  • Dizziness
  • Drowsiness
  • Dry mouth
  • Hot flashes
  • Headache
  • Loss of appetite
  • Nausea
  • Nervousness
  • Stomach pain or discomfort
  • Respiratory tract infections
  • Changes in taste
  • Fatigue
  • Insomnia
  • Weakness
  • Weight loss


It is important to contact a doctor immediately if you experience:


  • Rash
  • Urticaria
  • Itch
  • Difficulty breathing
  • Tightness in the chest
  • Swelling of the mouth, face, lips or tongue
  • Bone pain
  • Burning, numbness or tingling
  • Confusion
  • Loss of coordination
  • Decreased or painful urination
  • Persistent fever, chills, cough or sore throat
  • Loss of consciousness
  • Memory problems
  • Changes in menstrual cycle
  • Muscle or joint pain, cramps or weakness
  • Psychological problems or mood swings
  • Behavioral changes
  • Redness, swelling, blistering or peeling of the skin
  • Tinnitus
  • Severe or persistent drowsiness
  • Severe stomach, side or back pain
  • Massive weight loss
  • Trouble speaking
  • Numbness
  • Suicidal thoughts
  • Bleeding
  • Tremors
  • Difficulty concentrating
  • Trouble walking
  • Unusual eye movements


Contraindications and warnings associated with the use of Topiramate

Topiramate is contraindicated in cases where you are also taking metformin or if you suffer from metabolic acidosis.


Treatment with this medication can compromise the ability to drive and operate hazardous machinery. This side effect can be further aggravated by alcohol (which is highly advised against during treatment) and certain medications.


Furthermore, topiramate may reduce sweating and in turn increase body temperature (especially in children). The risk of this occurrence is higher during extremely hot temperatures and during strenuous physical exercise.